Ezogabine: a new angle on potassium gates.
نویسنده
چکیده
Ezogabine is a new drug for adjunctive therapy of partial-onset seizures with a novel mechanism of action. As a potassium-channel facilitator, it promotes membrane repolarization and thus opposes rapid repetitive discharges. Side effects are typical for antiepileptic drugs and the safety profile is good. Occasional instances of urinary difficulty may require surveillance.
منابع مشابه
Profile of ezogabine (retigabine) and its potential as an adjunctive treatment for patients with partial-onset seizures
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BACKGROUND Ezogabine (also known by the international nonproprietary name of retigabine) is an antiepileptic drug codeveloped and comarketed by Valeant Pharmaceuticals North America and GlaxoSmithKline, which reduces neuronal excitability by enhancing the activity of potassium channels and has the potential to have effects on the urinary system through a pharmacologic action on bladder smooth m...
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عنوان ژورنال:
- Epilepsy currents
دوره 11 3 شماره
صفحات -
تاریخ انتشار 2011